Article
Differential utilization of poly (A) signals between DHFR alleles in CHL cells.
Nucleic acids research - 25 Dec 1992
Scotto K W, Yang H, Davide J P, Melera P W
Abstract excerpt
The Chinese hamster cell line, DC-3F, is heterozygous at the DHFR locus, and each allele can be distinguished on the basis of a unique DNA restriction pattern, protein isoelectric profile and in the abundancy of the DHFR mRNAs it expresses. Although each allele produces four transcripts, 1000, 1650 and 2150 nucleotides [corrected] in length, the relative distribution of these RNAs differs for each; the 2150 nt...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Cricetinae
- Cricetulus
- Lung
- Molecular Sequence Data
- Mutagenesis
- Oligodeoxyribonucleotides
- Plasmids
- Poly A