Linkage studies on Gilles de la Tourette syndrome: what is the strategy of choice?

Article

Linkage studies on Gilles de la Tourette syndrome: what is the strategy of choice?

American journal of human genetics - 1 Aug 1995

Heutink P, van de Wetering B J, Pakstis A J, Kurlan R, Sandor P, Oostra B A, Sandkuijl L A

Abstract excerpt

For a linkage study it is important to ascertain family material that is sufficiently informative. The statistical power of a linkage sample can be determined via computer simulation. For complex traits uncertain parameters such as incomplete penetrance, frequency of phenocopies, gene frequency a...

Topics

Chromosome Mapping
Gene Frequency
Genetic Linkage
Humans
Lod Score
Pedigree
Phenotype
Tourette Syndrome

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