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Induction of the Human Papillomavirus Type 31 Late Promoter Requires Differentiation but Not DNA Amplification

28 Mar 2005

Abstract excerpt

The human papillomavirus (HPV) life cycle is linked to the differentiation state of the host cell. In virus-infected undifferentiated basal epithelial cells, HPV genomes are maintained as episomes at low copy number. Upon differentiation, a concomitant increase in viral copy number and an induction of late gene expression from a differentiation-specific promoter is seen. To investigate whether late gene...

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PMID: 15795277
DOI: 10.1128/jvi.79.8.4918-4926.2005

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