Article
E2 quasispecies specificity of hepatitis C virus association with allografts immediately after liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Feb 2004
Hughes Michael G, Rudy Christine K, Chong Tae W, Smith Robert L, Evans Heather L, Iezzoni Julia C, Sawyer Robert G, Pruett Timothy L
Abstract excerpt
It is unknown whether all hepatitis C virus (HCV) quasispecies variants found within patient serum have equal capacity to associate with the liver after transplantation; however, in vitro models of HCV infection suggest that variations in the hypervariable region 1 (HVR1) of the second envelope protein (E2) may be important in infectivity. The hypothesis of the current study is that the two hypervariable regions...
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