Article
Donor-recipient sharing of HLA class II alleles predicts earlier recurrence and accelerated progression of hepatitis C following liver transplantation.
Tissue antigens - 1 Nov 1998
Cotler S J, Gaur L K, Gretch D R, Wile M, Strong D M, Bronner M P, Carithers R L, Emond M J, Perkins J D, Nelson K A
Abstract excerpt
Both direct viral cytopathic effects and host immune responses appear to be important in the pathogenesis of hepatitis C virus (HCV) infection. Liver transplantation provides a means to explore the role of the immune system in the development of HCV-related liver damage through comparing the natu...
Topics
- Adult
- Alleles
- Disease Progression
- Female
- Hepatitis C, Chronic
- Histocompatibility
- Histocompatibility Antigens Class II
- Humans
- Liver Transplantation
- Male
- Middle Aged
- RNA, Viral
- Recurrence
- Time Factors