Article
A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART).
The Journal of antimicrobial chemotherapy - 1 Mar 2004
Stebbing Justin, Nelson Mark, Orkin Chloe, Mandalia Sundhiya, Bower Mark, Pozniak Anton, Gazzard Brian
Abstract excerpt
BACKGROUND: Treatment failure during highly active antiretroviral therapy (HAART) is ultimately common and associated with the development of resistance mutations to both the specific drug in question and cross-resistance to other available treatment options. In heavily pre-treated patients, the recycling of antiretroviral agents that have been utilized previously may, however, be associated with antiviral...
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