Article
BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2004
Kurozumi Kazuhiko, Nakamura Kiminori, Tamiya Takashi, Kawano Yutaka, Kobune Masayoshi, Hirai Sachie, Uchida Hiroaki, Sasaki Katsunori, Ito Yoshinori, Kato Kazunori, Honmou Osamu, Houkin Kiyohiro, Date Isao, Hamada Hirofumi
Abstract excerpt
Examination of the clinical therapeutic efficacy of using bone marrow stromal cells, including mesenchymal stem cells (MSC), has recently been the focus of much investigation. MSC were reported to ameliorate functional deficits after stroke in rats, with some of this improvement possibly resulting from the action of cytokines secreted by these cells. To enhance such cytokine effects, we transfected telomerized...
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