Article
GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas.
In vivo (Athens, Greece) - 1 Jan 2000
Oztürk Oguz, Isbir Turgay, Yaylim Ilhan, Kocatürk Celalettin I, Gürses Atilla
Abstract excerpt
BACKGROUND: In general, the metabolism of carcinogens involves two pathways. The oxidative pathway, which enhances carcinogenesis (phase I), and the protective pathway, in which carcinogens are conjugated with a series of substances such as glutathione to achieve detoxification (phase II). It has been suggested that an increased phase I enzyme activity (CYP1A1) and a decreased phase II enzyme activity (GST M1)...
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