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Article

Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein.

The Journal of biological chemistry - 23 Apr 2004

Farr Carol L, Matsushima Yuichi, Lagina Anthony T, Luo Ningguang, Kaguni Laurie S

Abstract excerpt

Functional interactions between mitochondrial DNA polymerase (pol gamma) and mitochondrial single-stranded DNA-binding protein (mtSSB) from Drosophila embryos greatly enhance the overall activity of pol gamma by increasing primer recognition and binding and stimulating the rate of initiation of DNA strands (Farr, C. L., Wang, Y., and Kaguni, L. S. (1999) J. Biol. Chem. 274, 14779-14785). We show here that...

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PMID: 14754882
DOI: 10.1074/jbc.M400283200

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