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Article

Regulation of <i>11β‐HSD</i> Genes in Human Adipose Tissue: Influence of Central Obesity and Weight Loss

1 Jan 2004

Abstract excerpt

OBJECTIVES: The activity of adipose 11beta-hydroxysteroid dehydrogenase (11beta-HSD) 1 is increased in obese subjects, and animal data suggest that increased cortisol formation in adipose tissue contributes to the development of the metabolic syndrome. The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level. RESEARCH...

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Share to Adrenal Hormones and Disorders
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PMID: 14742837
DOI: 10.1038/oby.2004.3

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