Article
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Gene therapy - 1 Feb 2004
Zhang Y C, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder R O, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford J M, Nick H S, Agarwal A, Ellis T M, Atkinson M A
Abstract excerpt
Adeno-associated virus (AAV) is widely considered a promising vector for therapeutic gene delivery. This promise is based on previous studies assessing AAVs safety and toxicity, ability to infect nondividing cells, elicit a limited immune response and provide long-term gene expression. However, we now find that earlier studies underappreciated the degree of AAV immunogenicity as well as the extent to which...
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