MAP kinases regulate unfertilized egg apoptosis and fertilization suppresses death via Ca²⁺ signaling

Abstract excerpt

The default fate for eggs from many species is death by apoptosis and thus, successful fertilization depends upon suppression of the maternal death program. Little is known about the molecular triggers which activate this process or how the fertilization signal suppresses the default maternal apoptotic pathway. The MAP kinase (MAPK) family member, ERK, plays a universal and critical role in several stages of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell death mechanisms and regulation
• Share to Reproductive Biology and Fertility
• Share to Sperm and Testicular Function