Article
A possible factor in genetic instability of cancer cells: stress-induced secreted proteins lead to decrease in replication fidelity.
Carcinogenesis - 1 Dec 1992
Boesen J J, Dieteren N, Bal E, Lohman P H, Simons J W
Abstract excerpt
Ultraviolet irradiation triggers a response in mammalian cells known as the UV response. Part of the UV response forms the enhanced synthesis of various extracellular proteins able to transmit the response to non-irradiated cells. Because several cancer-prone syndromes with enhanced genetic instability also have an enhanced synthesis of the same set of proteins without prior stimulation it is possible that...
Topics
- Animals
- Cell Division
- Culture Media, Conditioned
- Heat-Shock Proteins
- Hypoxanthine Phosphoribosyltransferase
- Lymphoma, T-Cell
- Male
- Mice
- Mutation
- Neoplasm Proteins
- Tumor Cells, Cultured