Article
Genetic markers of resistance to pyrimethamine and sulfonamides in Plasmodium falciparum parasites compared with the resistance patterns in isolates of Escherichia coli from the same children in Guinea-Bissau.
Tropical medicine & international health : TM & IH - 1 Jan 2004
Kofoed Poul-Erik, Alfrangis Michael, Poulsen Anja, Rodrigues Amabelia, Gjedde Susanne Borum, Rønn Anita, Rombo Lars
Abstract excerpt
The antifolate drugs sulphadoxine and pyrimethamine are used for treatment of chloroquine-resistant Plasmodium falciparum in Africa. Resistance to pyrimethamine has been associated with point mutations in the dhfr-gene and resistance to sulphadoxine with mutations in the dhps-gene. There is conce...
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