Article
Mass spectrometric phenotyping of Val34Leu polymorphism of blood coagulation factor XIII by differential peptide display.
Clinical chemistry - 1 Mar 2004
Tammen Harald, Möhring Thomas, Kellmann Markus, Pich Andreas, Kreipe Hans H, Hess Rüdiger
Abstract excerpt
BACKGROUND: The Val34Leu mutation in the activation peptide of factor XIII (FXIIIA) correlates with a lower incidence of myocardial infarction and ischemic stroke but an increased risk for hemorrhagic stroke. We describe mass spectrometric detection of the activation peptide variants in human serum. METHODS: We used differential peptide display (DPD) to compare comprehensive peptide maps from pairs of serum...
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