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Article

Ca2+-induced rolling of tropomyosin in muscle thin filaments: the alpha- and beta-band hypothesis revisited.

The Journal of biological chemistry - 9 Apr 2004

Holthauzen Luis M F, Corrêa Fernando, Farah Chuck S

Abstract excerpt

Tropomyosin is a filamentous coiled-coil protein directly involved in the regulation of the actomyosin interaction responsible for muscle contraction: it transmits the local calcium-induced conformational change in troponin to the helical array of myosin-binding sites on the surface of the actin...

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Identifiers

PMID: 14724287
DOI: 10.1074/jbc.M308904200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14724287-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Ca2+-induced rolling of tropomyosin in muscle thin filaments: the alpha- and beta-band hypothesis revisited.PMID 14724287Read ↗

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A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.Semantic proximity Read ↗

Emerging issues for tropomyosin structure, regulation, function and pathology.Semantic proximity Read ↗

Tropomyosin's periods are quasi-equivalent for actin binding but have specific regulatory functions.Semantic proximity Read ↗

Dual requirement for flexibility and specificity for binding of the coiled-coil tropomyosin to its target, actin.Semantic proximity Read ↗

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