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Article

Cell-based assay for the determination of temperature sensitive and cold adapted phenotypes of influenza viruses.

Journal of virological methods - 1 Mar 2004

Kiseleva I, Su Q, Toner T J, Szymkowiak C, Kwan W-S, Rudenko L, Shaw A R, Youil R

Abstract excerpt

The determination of temperature sensitive (ts) and cold adapted (ca) phenotype for influenza A and B strains has been conducted traditionally using embryonated chicken eggs. As attempts are made to move away from the use of eggs in the manufacturing process of influenza vaccines, it will become useful to develop cell-based assays to support cell culture-based vaccine production. In this study, MDCK cells have...

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PMID: 14715309
DOI: 10.1016/j.jviromet.2003.10.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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