Article
Parkin mutation associated parkinsonism and cognitive decline, comparison to early onset Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2004
Benbunan B R, Korczyn A D, Giladi N
Abstract excerpt
BACKGROUND: Patients with Parkinson's disease (PD) have cognitive changes resulting, presumably, from a progressive disruption of the functional integrity of frontostriatal circuitry. OBJECTIVE: To assess the cognitive state of two brothers with early onset autosomal recessive (EO-AR) parkinsonism and a large deletion in the parkin gene, and to compare it to that of patients with sporadic young onset PD (YOPD)....
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