Article
A human CTL recognizes a caspase-8-derived peptide on autologous HLA-B*3503 molecules and two unrelated peptides on allogeneic HLA-B*3501 molecules.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2000
Mandruzzato S, Stroobant V, Demotte N, van der Bruggen P
Abstract excerpt
A CTL clone that recognizes autologous tumor cells was previously isolated from the blood of a head-and-neck cancer patient. The Ag was identified as peptide FPSDSWCYF presented by autologous HLA-B*3503 molecules. This peptide was encoded by a mutated CASP-8 gene, which is implicated in the trigg...
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