Article
Stability of homologue of Slimb F-box protein is regulated by availability of its substrate.
The Journal of biological chemistry - 19 Mar 2004
Li Ying, Gazdoiu Stefan, Pan Zhen-Qiang, Fuchs Serge Y
Abstract excerpt
The homologue of Slimb (HOS) F-box protein is a receptor of the Skp1-Cullin1-F-box protein (SCF(HOS)) E3 ubiquitin ligase, which mediates ubiquitination and degradation of beta-catenin and the inhibitor of NFkappaB, IkappaB. We found that HOS itself is an unstable protein that undergoes ubiquitination and degradation in a 26 S proteasome-dependent manner. A HOS mutant lacking the F-box that is deficient in...
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