Article
HLA haplotypes associated with type 1 diabetes mellitus in North Indian children.
Human immunology - 1 Jan 2004
Kanga Uma, Vaidyanathan Balu, Jaini Ritika, Menon Puthezath S N, Mehra Narinder K
Abstract excerpt
Human leukocyte antigen (HLA) encoded susceptibility to develop type 1 diabetes mellitus (T1DM) has been investigated in children from North India. The results revealed significantly increased prevalence of HLA-A26, -B8, and -B50 among patients and strong positive association of the disease with DRB1*0301 (82.1% vs 13.9%, chi2=71.3, odds ratio [OR]=28.3) and a negative association with DRB1*02 (chi2=12.2,...
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