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Article

PDGFRA Is Not Essential for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines.

Stem cell reports - 10 Oct 2017

Lin Jiangwei, Khan Mona, Zapiec Bolek, Mombaerts Peter

Abstract excerpt

Extraembryonic endoderm stem (XEN) cell lines can be derived and maintained in vitro and reflect the primitive endoderm lineage. Platelet-derived growth factor receptor alpha (PDGFRA) is thought to be essential for the derivation and maintenance of mouse XEN cell lines. Here, we have re-evaluated this requirement for PDGFRA. We derived multiple PDGFRA-deficient XEN cell lines from postimplantation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28919262
DOI: 10.1016/j.stemcr.2017.08.005
PMCID: PMC5639183

Genes

PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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