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Article

hnRNP L enhances sensitivity of the cells to KW-2189.

International journal of cancer - 20 Feb 2004

Taguchi Fumiko, Kusaba Hitoshi, Asai Akira, Iwamoto Yasuo, Yano Keiichi, Nakano Hirofumi, Mizukami Tamio, Saijo Nagahiro, Kato Harubumi, Nishio Kazuto

Abstract excerpt

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are involved in several RNA-related biological processes. We demonstrated hnRNP L as a candidate protein of DARP (duocarmycin-DNA adduct recognizing protein) by gel shift assay and amino acid sequencing. Stable transfectants of hnRNP L showed high sensitivity of the cells to the growth inhibitory effect of KW-2189, a duocarmycin derivative in vitro. Immunostaining...

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PMID: 14696094
DOI: 10.1002/ijc.11616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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