Article
Modeling familial clustered breast cancer using published data.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2003
Jonker M A, Jacobi C E, Hoogendoorn W E, Nagelkerke N J D, de Bock Geertruida H, van Houwelingen Johannes C
Abstract excerpt
The purpose of this research was to model the familial clustering of breast cancer and to provide an accurate risk estimate for individuals from the general population, based on their family history of breast and ovarian cancer. We constructed a genetic model as an extension of a model by Claus et al. (E. B. Claus et al., Am. J. Hum. Genet., 48: 232-242, 1991), with three breast cancer genes, BRCA1, BRCA2, and a...
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