Article
Mutational analysis of the predicted secondary RNA structure of the Mason-Pfizer monkey virus packaging signal.
Virus research - 1 Jan 2004
Mustafa Farah, Lew Kathy A, Schmidt Russell D, Browning Mathew T, Rizvi Tahir A
Abstract excerpt
The 5' end of the Mason-Pfizer monkey virus (MPMV) genomic RNA has been predicted to fold into a complex stem/loop structure that is thought to play a role in specific RNA encapsidation. In this study, we used a set of mutations that either abrogated or recreated the first four stem loops predicted within the 5' untranslated region (5' UTR) for effects on RNA packaging. Test of these mutations in our biological...
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