Article
The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting.
Chinese medical journal - 20 Sept 2005
Li Ping, Elrayess Mohamed A, Gomma Abuzeid H, Palmen Jutta, Hawe Emma, Fox Kim M, Humphries Steve E
Abstract excerpt
BACKGROUND: Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT) n repeats that has been reported to differently induce gene expression....
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