Article
Genetic variation in oocyte phenotype revealed through parthenogenesis and cloning: correlation with differences in pronuclear epigenetic modification.
Biology of reproduction - 1 Apr 2004
Gao Shaorong, Czirr Eva, Chung Young Gie, Han Zhiming, Latham Keith E
Abstract excerpt
Previous studies revealed that oocytes of different genetic strains (e.g, C57BL/6 and DBA/2) modify maternal and paternal pronuclei differently, affecting early preimplantation development. To determine whether these strain-dependent effects would also apply to oocyte modifications of somatic cell nuclei introduced during cloning procedures, we compared the efficiency of development of parthenogenetic and cloned...
Topics
- Animals
- Carrier Proteins
- Cloning, Organism
- Embryonic and Fetal Development
- Female
- Genetic Variation
- Genotype
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Oocytes
- Parthenogenesis
- Phenotype
- Tissue Donors