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Gene targeting demonstrates that the<i>Plasmodium berghei</i>subtilisin PbSUB2 is essential for red cell invasion and reveals spontaneous genetic recombination events

12 Dec 2003

Abstract excerpt

The Plasmodium merozoite proteases involved in the crucial process of erythrocyte invasion are promising targets for novel malaria control strategies. We report here the characterization of the subtilisin-like protease SUB2 from the rodent parasites Plasmodium berghei and Plasmodium yoelii, leading the way to in vivo functional studies of this enzyme. The kinetics of expression and subcellular localization imply...

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PMID: 14678331
DOI: 10.1046/j.1462-5822.2003.00343.x

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