Article

Investigating the mechanisms underlying Bortezomib resistance

2023-07-31

Abstract excerpt

Proteasome inhibitors such as Bortezomib, represent an established type of targeted treatment for several types of hematological malignancies, including multiple myeloma, Waldenstrom’s macroglobulinemia and mantle cell lymphoma, based on the cancer cell’s susceptibility upon impairment of the proteasome-ubiquitin system. However, a major problem limiting their efficacy is the emergence of resistance. Their applica...

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Literature Corpus work: b6ea6c16-a700-5c30-8c0f-2d4f1d066840
DOI: 10.1101/2023.07.29.551081

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