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Article

Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation.

Cancer research - 1 Jul 2012

Hutti Jessica E, Pfefferle Adam D, Russell Sean C, Sircar Mayukh, Perou Charles M, Baldwin Albert S

Abstract excerpt

The phosphoinositide 3-kinase (PI3K) pathway is one of the most commonly misregulated signaling pathways in human cancers, but its impact on the tumor microenvironment has not been considered as deeply as its autonomous impact on tumor cells. In this study, we show that NF-κB is activated by the...

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Source

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Identifiers

PMID: 22552288
DOI: 10.1158/0008-5472.CAN-11-4141
PMCID: PMC3541677

Genes

EGF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22552288-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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