Article
The impact of progesterone on simultaneous, local secretion of IGFBP-3 and IGF-I [IGFBP-3/IGF-I index] by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype.
Ginekologia polska - 1 Sept 2003
Krzysiek Józef, Milewicz Tomasz, Augustowska Katarzyna, Sztefko Krystyna, Ryś Janusz, Zubel Angela, Pityński Kazimierz, Jaszczyński Piotr, Herman Krzysztof, Basta Antoni, Stachura Jerzy, Gregoraszczuk Ewa Ł
Abstract excerpt
OBJECTIVES: Insulin-like growth factor-I (IGF-I) is regarded as one of mammary tissue proliferative factors. Insulin-like growth factor binding protein-3 (IGFBP-3) limits the IGF-I binding potential to its receptor. That limits the IGF-I bioavailability. Recently experimental studies indicated that insulin-like growth factor binding proteins (IGFBPs) might have their own biological actions beyond their ability to...
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