Article
Binding of AP-2 and ETS-domain family members is associated with enhancer activity in the hypersensitive site III region of the human growth hormone/chorionic somatomammotropin locus.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Jin Yan, Norquay Lisa D, Yang Xiaoyang, Gregoire Scott, Cattini Peter A
Abstract excerpt
The human GH gene family is specifically expressed in somatotrophs of the anterior pituitary and placental syncytiotrophoblast. Two nuclease-hypersensitive sites, HS III and HS V, are associated with a region of chromatin located 28 and 30 kb upstream of the pituitary GH gene transcription initiation site (+1) in both pituitary and placenta nuclei. A role for this region in pituitary GH gene expression has been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.