Article
Mutations of the hemochromatosis gene in Italian candidate blood donors with increased transferrin saturation.
The hematology journal : the official journal of the European Haematology Association - 1 Jan 2003
Velati Claudio, Marlianici Eugenia, Rigamonti Danila, Barillari Giovanni, Chiavilli Francesco, Fugiani Paolo, Garozzo Giovanni, Lancieri Mario, Rinaldi Sandro, Testa Domenico, Sampietro Maurizio, Tavazzi Dario, Delbini Paola, Fargion Silvia, Fiorelli Gemino
Abstract excerpt
The aim of this study was to analyze the role of HFE mutations in blood donors with iron parameters suggesting iron overload, taking into account the regional distribution of HFE mutations in Italy. We studied 5880 subjects undergoing evaluation for blood donation eligibility, from different areas of Italy. Abnormal iron parameters were defined as transferrin saturation (TS) >50% or >45% and serum ferritin (SF)...
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