Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited.

doi:10.1016/0167-5699(92)90170-C

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Article

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited.

Immunology today - 1 Sept 1992

Harrison L C

Abstract excerpt

A major goal of research into IDDM has been the identification of the 'causative antigen'. As described in this article by Len Harrison, this reductionist aim is confounded by the fact that numerous candidate islet cell antigens have been described. He scrutinizes the credentials of these candidates and discusses the problem of using autoantibodies to identify causative antigens in a T-cell-mediated disease.

Topics

Autoantibodies
Autoantigens
Autoimmune Diseases
Cytoplasmic Granules
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
Glutamate Decarboxylase
Humans
Immunity, Cellular
Insulin
Intracellular Membranes

Islets of Langerhans

Isoenzymes

Models, Biological

T-Lymphocytes, Cytotoxic

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