Article
Functional characterization of the polyketide synthase gene required for ochratoxin A biosynthesis in Penicillium verrucosum.
International journal of food microbiology - 15 Feb 2013
Abbas Abdelhamid, Coghlan Avril, O'Callaghan John, García-Estrada Carlos, Martín Juan-Francisco, Dobson Alan D W
Abstract excerpt
The ochratoxin A (OTA) polyketide synthase otapks gene has been cloned from Penicillium verrucosum. A P. verrucosum mutant in which the otapksPV gene has been interrupted cannot synthesize ochratoxin A. The protein is most similar to the citrinin polyketide synthase CtnpksMa from Monascus anka (83% identity at the amino acid level). Different nutritional conditions influence OTA production in P. verrucosum, with...
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