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Article

Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.

The Journal of biological chemistry - 26 Mar 2004

Gensler Miriam, Buschbeck Marcus, Ullrich Axel

Abstract excerpt

Signaling by receptor tyrosine kinases (RTK) mediates a variety of complex cellular functions and in case of deregulation can contribute to pathophysiological processes. A tight and finely tuned control of RTK activity is therefore critical for the cell. We investigated the role of the PEST-type protein-tyrosine phosphatase BDP1 in the regulation of HER2, a member of the epidermal growth factor receptor (EGFR)...

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Source

Identifiers

PMID: 14660651
DOI: 10.1074/jbc.M309527200

Genes

BDP1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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