Article
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology - 1 Jun 2020
Xu Xiaozheng, Hou Bowen, Fulzele Amitkumar, Masubuchi Takeya, Zhao Yunlong, Wu Zijun, Hu Yanyan, Jiang Yong, Ma Yanzhe, Wang Haopeng, Bennett Eric J, Fu Guo, Hui Enfu
Abstract excerpt
Blockade antibodies of the immunoinhibitory receptor PD-1 can stimulate the anti-tumor activity of T cells, but clinical benefit is limited to a fraction of patients. Evidence suggests that BTLA, a receptor structurally related to PD-1, may contribute to resistance to PD-1 targeted therapy, but how BTLA and PD-1 differ in their mechanisms is debated. Here, we compared the abilities of BTLA and PD-1 to recruit...
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