Article
Apocytolysis, a proposed mechanism of blister formation in epidermolysis bullosa simplex.
Archives of dermatological research - 1 May 2015
El-Hawary Marwa S, Abdel-Halim Mona R E, Sayed Safinaz S, Abdelkader Heba A
Abstract excerpt
Epidermolysis bullosa simplex (EBS) is caused by keratin 5 and 14 mutations. In vitro studies revealed that susceptibility to caspase 8-mediated apoptosis is increased in keratin 14 mutated keratinocytes. We aimed to investigate the role of apoptotic/inflammatory pathways in the pathogenesis of E...
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