Article
A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.
The Journal of biological chemistry - 20 Feb 2004
Arimura Takuro, Hayashi Takeharu, Terada Hajime, Lee Su-Yeoun, Zhou Qiang, Takahashi Megumi, Ueda Kazuo, Nouchi Tatsuhito, Hohda Shigeru, Shibutani Makoto, Hirose Masao, Chen Ju, Park Jeong-Euy, Yasunami Michio, Hayashi Hideharu, Kimura Akinori
Abstract excerpt
Dilated cardiomyopathy is characterized by ventricular dilation with systolic dysfunction of cardiac muscle. Recent genetic studies have revealed that mutations in genes for cytoskeleton proteins distributed in the Z-disc and/or intercalated discs of the cardiac muscle are major predictors of cardiomyopathy. However, as mutations in these genes can account for only a part of the patient population, there should...
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