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Article

Catalysis and rotation of F1 motor: cleavage of ATP at the catalytic site occurs in 1 ms before 40 degree substep rotation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Shimabukuro Katsuya, Yasuda Ryohei, Muneyuki Eiro, Hara Kiyotaka Y, Kinosita Kazuhiko, Yoshida Masasuke

Abstract excerpt

F1, a water-soluble portion of FoF1-ATP synthase, is an ATP hydrolysis-driven rotary motor. The central gamma-subunit rotates in the alpha 3 beta 3 cylinder by repeating the following four stages of rotation: ATP-binding dwell, rapid 80 degrees substep rotation, interim dwell, and rapid 40 degrees substep rotation. At least two 1-ms catalytic events occur in the interim dwell, but it is still unclear which steps...

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Identifiers

PMID: 14657340
DOI: 10.1073/pnas.2434983100
PMCID: PMC299784

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