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Article

Molecular mechanism of ATP hydrolysis in F1-ATPase revealed by molecular simulations and single-molecule observations.

Journal of the American Chemical Society - 23 May 2012

Hayashi Shigehiko, Ueno Hiroshi, Shaikh Abdul Rajjak, Umemura Myco, Kamiya Motoshi, Ito Yuko, Ikeguchi Mitsunori, Komoriya Yoshihito, Iino Ryota, Noji Hiroyuki

Abstract excerpt

Enzymatic hydrolysis of nucleotide triphosphate (NTP) plays a pivotal role in protein functions. In spite of its biological significance, however, the chemistry of the hydrolysis catalysis remains obscure because of the complex nature of the reaction. Here we report a study of the molecular mechanism of hydrolysis of adenosine triphosphate (ATP) in F(1)-ATPase, an ATP-driven rotary motor protein. Molecular...

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PMID: 22548707
DOI: 10.1021/ja211027m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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