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Article

The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Oct 2003

Sartori Maria Teresa, Danesin Cristina, Saggiorato Graziella, Tormene Daniela, Simioni Paolo, Spiezia Luca, Patrassi Giovanni Maurizio, Girolami Antonio

Abstract excerpt

Genetic and acquired factors may influence phenotypic expression of inherited thrombophilia. Hypofibrinolysis due to excess PAI-1 can be found in patients with deep vein thrombosis (DVT) and 4G/5G polymorphism of the PAI-1 gene may modulate the inhibitor's synthesis. In 149 patients with inherited thrombophilia, the possible thrombotic contribution of both 4G/5G polymorphism and PAI-1 plasma levels was evaluated....

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Identifiers

PMID: 14653439
DOI: 10.1177/107602960300900405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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