Article
4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis.
Thrombosis and haemostasis - 1 Dec 1998
Sartori M T, Wiman B, Vettore S, Dazzi F, Girolami A, Patrassi G M
Abstract excerpt
A deletion/insertion polymorphism (4G or 5G) in the promoter of the plasminogen activator inhibitor type 1 gene has been suggested to be involved in regulation of the synthesis of the inhibitor, the 4G allele being associated with enhanced gene expression. A relationship between 4G/5G polymorphis...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Blood Coagulation Tests
- Female
- Fibrinolysis
- Gene Expression Regulation
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Mutagenesis, Insertional
- Plasminogen Activator Inhibitor 1
- Polymorphism, Genetic
- Promoter Regions, Genetic