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Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny

24 Nov 2023

Abstract excerpt

Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Hertwig's epithelial root sheath (HERS) induces odontoblast differentiation and the subsequent radicular dentin deposition. Precisely controlled signaling pathways modulate the behaviors of HERS and the fates of dental mesenchymal stem cells (DMSCs). Disruptions in these pathways lead to defects...

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PMID: 38001110
DOI: 10.1038/s41368-023-00258-9

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