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HumanImmunodeficiency Virus Type 1 DNA Nuclear Import and Integration AreMitosis Independent in CyclingCells

25 Nov 2003

Abstract excerpt

An essential step in human immunodeficiency virus type 1 (HIV-1) replication is the movement of the viral preintegration complex from the cytoplasm into the nucleus. The pathway(s) and timing for HIV-1 DNA nuclear entry in cycling cells have not been established. Here, we show that if cycling cells are infected before S phase, viral DNA can be integrated prior to passage of the host DNA replication fork through...

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PMID: 14645598
DOI: 10.1128/jvi.77.24.13412-13417.2003

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