Article
Selective antagonism of rat inhibitory glycine receptor subunits.
The Journal of physiology - 1 Feb 2004
Han Yi, Li Ping, Slaughter Malcolm M
Abstract excerpt
Retinal ganglion cells exhibit fast and slow inhibitory synaptic glycine currents that can be selectively inhibited by strychnine and 5,7-dichlorokynurenic acid (DCKA), respectively. In this study we examined whether strychnine and DCKA selectivity correlated with the subunit composition of the glycine receptor. Homomeric alpha1, alpha2 or alpha2* glycine subunits were in vitro expressed in human embryonic kidney...
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