Article
Association of intercellular adhesion molecule-1 gene with type 1 diabetes.
Lancet (London, England) - 22 Nov 2003
Nejentsev Sergey, Guja Cristian, McCormack Rose, Cooper Jason, Howson Joanna M M, Nutland Sarah, Rance Helen, Walker Neil, Undlien Dag, Ronningen Kjersti S, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Ionescu-Tirgoviste Constantin, Gale Edwin A M, Bingley Polly J, Gillespie Kathleen M, Savage David A, Carson Dennis J, Patterson Chris C, Maxwell A Peter, Todd John A
Abstract excerpt
Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease....
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