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Article

Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy.

Epilepsia - 1 Nov 2003

Sisodiya Sanjay M, Martinian Lillian, Scheffer George L, van der Valk Paul, Cross J Helen, Scheper Rik J, Harding Brian N, Thom Maria

Abstract excerpt

PURPOSE: The molecular basis of drug resistance in epilepsy is being explored. Two proteins associated with drug resistance in cancer, P-glycoprotein and multidrug resistance-associated protein 1, are upregulated in human epileptogenic pathologies. Other proteins associated with resistance in cancer include major vault protein (MVP) and breast cancer resistance protein (BCRP). We hypothesized that these proteins...

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Source

Identifiers

PMID: 14636345
DOI: 10.1046/j.1528-1157.2003.21803.x

Genes

MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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