Article
A functional variant of the iNOS gene flanking region is associated with LAD coronary artery disease: an autopsy study.
European journal of clinical investigation - 1 Dec 2003
Kunnas T A, Mikkelsson J, Ilveskoski E, Tanner M M, Laippala P, Penttilä A, Perola M, Nikkari S T, Karhunen P J
Abstract excerpt
BACKGROUND: Recent studies using reporter gene constructs have indicated significant differences in the promoter activity of inducible nitric oxide synthase (iNOS) gene variants. Although the exact role of iNOS in atherogenesis is unclear, it is possible that this variation site may influence the extent of coronary artery disease (CAD). METHODS: We amplified these (AAAT) repeat variants from the NOS2A gene...
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