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Article

Association of the endothelial nitric oxide synthase gene polymorphism with risk of coronary artery disease and myocardial infarction in middle-aged men.

Journal of molecular medicine (Berlin, Germany) - 1 Sept 2002

Kunnas Tarja A, Ilveskoski Erkki, Niskakangas Tero, Laippala Pekka, Kajander Olli A, Mikkelsson Jussi, Goebeler Sirkka, Penttilä Antti, Perola Markus, Nikkari Seppo T, Karhunen Pekka J

Abstract excerpt

Nitric oxide (NO), formed by endothelial constitutive nitric oxide synthase (eNOS) maintains endothelium-dependent vasodilatation and also mediates antithrombotic actions. The eNOS gene harbours a common polymorphism in intron 4 (4a/b), and some clinical studies have suggested an association of the rare a-allele with coronary artery disease (CAD) and myocardial infarction (MI). However, contradictory results have...

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Identifiers

PMID: 12226742
DOI: 10.1007/s00109-002-0365-z

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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